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This text provides a guide to the methods available and the techniques currently used in the area. It provides late-1990s' information and guidance on the methods and strategy used in developing and running ultra-trace analyses for drugs, metabolites and other substances. The author writes in an informal and didactic style, offering a logical path through the problems of small-molecule (bio)analysis and should enable readers to choose appropriate methods of analysis for their needs.

In the seven years since the publication of Principles and Practice of Bioanalysis bioanalytical methods have remained the same, but their usage patterns have changed. This second edition of a bestseller provides an updated guide to the techniques used in developing and running ultra-trace analyses for drugs, metabolites, and other substances.

Extensively revised, this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Each chapter has been overhauled or re-written to reflect modern practice. Experts in the field offer a logical path...