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What is the connection between: the court-martial of a Union Army Colonel and the ABSCAM scandal; President Garfield's assassin Charles Guiteau and former Vice President Al Gore; the conviction of New York "sawdust swindler" Sam Hayes and lobbyist Jack Abramoff; and President Theodore Roosevelt and former New York Yankee owner George Steinbrenner III? If you answered "corruption," you are right, but only partly so.The Original Sins: America's Fight Against Corruption in the Era of Manifest Destiny tells the stories behind America's efforts to define and prevent corruption in our national...

What is the connection between: the court-martial of a Union Army Colonel and the ABSCAM scandal; President Garfield's assassin Charles Guiteau and former Vice President Al Gore; the conviction of New York "sawdust swindler" Sam Hayes and lobbyist Jack Abramoff; and President Theodore Roosevelt and former New York Yankee owner George Steinbrenner III? If you answered "corruption," you are right, but only partly so.The Original Sins: America's Fight Against Corruption in the Era of Manifest Destiny tells the stories behind America's efforts to define and prevent corruption in our national...

The human genome and other large-scale genome sequencing projects have inevitably led to a focus on the proteins encoded by genes. The field of proteomics has grown enormously as a result and a number of high-throughput technologies have now been developed allowing discovery-led investigations of protein populations rather than more traditional hypothesis-led studies on single proteins. These high-throughput techno- gies include gene and protein microarrays, the yeast two-hybrid system, and various mass spectrometry methodologies. However, despite developments and improvements in these...