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Molecular conformation of molecule is influenced by several non-covalent interactions such as H-bonding, stacking interaction, exerted by surrounding molecules. The Weak interactions persuade the very decisive role in stabilizing geometrical arrangement of molecules. The present study deals with this particular approach. In order to develop new flexible models for studying aromatic interaction, 3-cyano-4,6-dimethyl,2-oxo-nicotinonitrile, and 4-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine based flexible models have been synthesized. We have synthesized polymethylene and methyl benzene linked...

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability...