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Over the past two decades there has been a growing appreciation on the importance of circadian rhythms on GIT physiology and on disease states, together with the realization of the significance of time-of-day of drug administration on resultant pharmacodynamic and pharmacokinetic parameters. The significance of these day-night variation has not been overlooked from the drug delivery perspective and pharmaceutical scientist has displayed considerable intenuity in the development of time delayed drug delivery system to address emerging chronotherapeutic formulation. In the present study,...