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Ceramide are family of lipid molecules. Ceramide consist of a Long-chain or Sphingoid base linked to a fatty acid via an amide bond. Ceramide has emerged as a key regulator of a wide spectrum of biological processes such as cellular differentiation, proliferation, programmed cell death (PCD), and apoptosis of cells. Cell proliferation studies were carried out in chemically induced rat hepatocarcinogenesis. Immunostaining of PCNA, Ki-67 and BrdU results revealed that, Group C rats showed a minimal PCNA expression, decrement in ki-67 expression and Low BrdU labeling suggesting the suppressive...

Ranolazine is used for the treatment of Angina pectoris, which has a short half-life of 1.4-1.9 hours. Ranolazine floating tablets were prepared by direct compression technique using polymers such as HPMC, Carbopol 934P and Chitosan. Tablets were evaluated for its physical properties, viz. hardness, friability, weight variation, In vitro Buoyancy, swelling studies, In vitro drug release and In-vivo gastric Residence time. Drug release kinetics was studied for zero order, first order, Higuchi and Korsmeyer-Peppas. Finally, it can be concluded that promising controlled release by gastro...