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DNA triple helices are formed by the binding of a third strand oligomer in the major groove of a Watson -Crick (WC) duplex. Interest in triple-helical nucleic acids-that is, triplex has been stimulated by the recognition of their potential biological roles and genetic applications. Although direct evidence of participation of triplexes in biological processes has not yet been obtained, there are ample data to suggest that triplexes can be involved in regulation of DNA replication, transcription, recombination and development.During DNA triplex formation third oligonucleotide strands binds...

This monograph is based on the research done at Department of Physics, DDU Gorakhpur University Gorakhpur,India on unusual DNA structures.Department s laboratory is pioneer in the field of Computational Modeling, Quantum mechanics and Molecular Mechanics simulations (QM/MM) on bio-molecules. Several high end research articles and theses have been produced during last 10 years form the laboratory. The aim of writing this book is to provide an easy tool/manual to understand nucleic acids, its modeling, QM/MM simulations, conformation and biological functions to the graduate level students and...