Wyniki wyszukiwania:

Thrombosis and atherosclerosis associated with the rupture of vulnerable plaque are the root cause of cardiovascular events leading to serious consequences such as myocardial or cerebral infarction, at times leading to death. Anticipation of thrombogenesis has become one of the most vital targets in the prophylaxis and therapy of cardiocirculatory disorders with atherothrombotic complications. As of the shortcomings of available drugs for treating such ailments, attempts are underway to explore natural sources with protective efficacy on cardiocirculatory disorders. Herbal medicines as the...

Herbal medicines as the key remedy in traditional system of medicine have been used in medical practices since antiquity. The practices continue today as of its biomedical benefits as well as place in cultural beliefs in many parts of world and have made a great contribution towards maintaining human health. Traditional knowledge driven bioprospecting offers access to multiple targets that can provide safer and more cost effective platform for newer scaffolds to facilitate drug discovery. The presence of various health sustaining constituents in plants have activated scientists to examine...

Gemcitabine is a nucleoside analogue, used in various carcinomas such as non small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. The major setbacks to the conventional therapy with gemcitabine include its short half-life and highly hydrophilic nature. The objectives of this investigation were to synthesize lipophilic derivative of gemcitabine, evaluate the physiochemical properties, entrapment efficiency, in vitro release, cytotoxicity, and cellular uptake of nanoparticulate formulations containing gemcitabine and stearoyl gemcitabine. We successfully prepared a...