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Amongst all carrier utilized for target oriented drug delivery, vesicular drug delivery system in the form of liposome is most extensively investigated. Liposomes are gaining popularity because of their inert biological nature, freedom from antigenic, pyrogenic or allergic reactions and similarity of primary components of liposomes with natural membrane. Human Immunodeficiency Virus (HIV) is a retrovirus that causes irreversible destruction of immune system, leading to occurrence of opportunistic infection and malignancy. During last decade, even though attempts were being made to eradicate...

Separation of therapeutic effects from toxicity is a valuable goal in the drug development process. Prodrug design is a part of the general drug discovery process, in which a unique combination of therapeutically active substances is observed to have desirable pharmacological effects. In human therapy prodrug designing has given successful results in overcoming undesirable properties like absorption, nonspecificity, and poor bioavailability and GIT toxicity. Prodrug design is opening new doors in the challenging field of drug discovery, revolutionizing the art of Drug development.In this...

A number of drugs are introduced in the market every year, also many new fixed dose combinations of already individually approved drugs are formulated with an aim to achieve better therapeutic efficacy. Pharmaceutical products formulated with more than one drug, typically referred to as combination products, are intended to meet previously unmet patients need by combining the therapeutic effects of two or more drugs in one product. These combination products can present daunting challenges to the analytical chemist responsible for the development and validation of analytical...