Effects of microtubule-interfering agents on AhR signalling

ISBN-13: 9783659180224 / Angielski / Miękka / 2012 / 100 str.

Radim Vrzal

Opis

Microtubule-interfering agents are compounds which affect microtubules network. They found use in cancer therapy (vinblastine, paclitaxel) or as anti-inflammatory agents (colchicine). Present work focuses on the effect of these compounds in signalling of aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor regulating expression of many genes, some of them being involved in biotransformation of carcinogens.

O autorze

Radim Vrzal,received his PhDs from Palacky University in Olomouc (Czech Republic) and Université Montpellier 1 (France). Now, he is an associate professor at Palacky University. His research is focused on drug metabolism, biological activity of natural compounds, biotransformation enzymes and their regulation by nuclear receptors.