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The systemic delivery of drugs through novel methods of administration is one area in which significant changes and improvements have been made. Consequently, precise control of drug input into the body by a variety of routes is now possible.This study presents an idea of development of mucoadhesive buccal patch of Labetalol hydrochloride by using chitosan, PVP K 30, PVP K 90, HPMC, and polyethylene glycol(PEG)1000. The prepared patches were evaluated for their weight variation, thickness, folding endurance, swelling index, surface pH, drug content uniformity and in vitro release st