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In today's scientific world, the peptide therapeutics has gained more attention due its safety, efficacy, selectivity and specificity. In this book the authors intended to describe the simple and significant key factors that have to be considered in designing effective peptide chelators for five carcinogenic metals. These factors were derived from observing the coordination geometry of metal within its coordination sphere in a protein. Data are derived from experimentally validated structures and hence the results presented are reliable and valid. The book provides a novel strategy by...

Mucin1 is an important tumor marker, and is notable for the autoproteolytic event, a signature of all SEA domain containing proteins. This work reports an in silico, study of the structural and functional significance of the 18 residue insert in the autoproteolytic process and also the peptide inhibitors for preventing its receptor-ligand alliance. It also reports ligand scaffolds that could effectively participate in inhibition of autoproteolysis of mucin 1. The study reveals both isoforms to poses an intact SEA domain, with an altered functional scaffold around the cleavage site. Mutation...