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A number of lesions that affect the jaws typically display multinucleated giant cells as one of their histopathologic components. Such a list would include infectious granulo-matous processes, response to exogenous material such as giant cell hyaline angiopathy, and benign neoplasm including osteoblastoma, cementoblastoma, juvenile active ossifying fibroma, chondroblastoma, chondromyxoid fibroma, and several malignant bone tumors. Additionally, several other entities occur in which giant cells are the predominant histologic finding and the basis for their recognition. This latter group of...