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Over the last two decades, the pharmaceutical scientists extensively probed in the area of colonic region for targeted drug delivery system. The present research is deals with the development of flurbiprofen colon targeted compression coated tablets to retard the drug release in the upper gastro intestinal system but progressively release in the colon. Combination of time dependent and pH sensitive approaches was suitable to target the flurbiprofen to colon. This work explains the detailed explanation on formulation, in vitro characterization, in vivo x-ray imaging studies and in vivo...