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Experimental gerontological research is necessary to obtain optimal information and thus ensure proper drug therapy for the elderly. Most older persons acquire multiple diseases, first of all chronic diseases. They involve complex problems of a physical, social, and psychological nature. The multimorbidity of the elderly raises many questions in drug therapy. By contrast with our extensive knowledge of pharmacokinetics and pharmacodynamics in younger age groups, few facts are available in respect of the elderly. A variety of factors may influence drug therapy. Physiological and pathological...

Im h-heren Lebensalter nimmt die Zahl der Erkrankungen zu. Oft m}ssen mehrere Medikamente gleichzeitig eingesetzt werden. Durch die altersbedingten Organver{nderungen wird jedoch die Wirkung der Medikamente beeinflu t. Die vorliegende 2. }berarbeitete und durch drei neue Kapitel (Therapie arterieller Durchblutungsst-rungen; Therapie der koronaren Herzkrankheit; Therapie von Schilddr}senerkrankungen) erweiterte Auflage beschreibt die besonderen Probleme und die sinnvolle Anwendung der Pharmakotherapie bei {lteren Patienten. Nach einleitenden Ausf}hrungen }ber den Einflu von Altersver{nderungen...

At the beginning of the century the average life span in developed societies was less than 50 years. It is now more than 70 years and will continue to increase in the near future. Aging is a challenge to science and society. There are several theories of aging. The programmed aging hypothesis suggests that aging cannot be altered by any external influence, that aging is programmed from the beginning of life until the end of senescence. Another theory is based on genetic instability, with repair processes correcting errors in the cells that cause aging. Aging processes manifest themselves at...