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In present work a model corn zein-based medicated chewing gum for motion sickness was developed. A modified fusion method suggested by Mc Gowan and co workers was used for the preparation of corn zein MCG. Based on the results of RSM (Response surface methodology) studies corn zein concentration of 57.6 % w/w was optimized and used in the current study. Various formulations of corn zein MCG samples were prepared varying only the plasticizer content (MCG-1 to MCG-10). The corn zein MCG formulations were prepared using various plasticizers like (A) PEG 4000, (B) PEG 200, (C) PEG-300, (D)...

Transcutaneous drug delivery has many theoretical and practical advantage and disadvantages, and such issues are often a concern for both clinicians and patients. Transcutaneous patches are flexible pharmaceutical preparations of varying sizes, containing one or more active ingredient, intended to be applied to the unbroken skin in order to deliver the active ingredient to the systemic circulation after passing through the skin barriers. A transcutaneous patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin into...