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Despite huge media attention and public awareness, more dedicated publications, recent advances in pharmaceutical and medical device developments, heart disease in women is under-diagnosed, under-treated, and under-managed. What is wrong? Why? Many women fail to present in the clinic when symptomatic because of their responsibilities to the home, children and work. Often the first presentation follows a cardiac event. For many multicenter clinical trials, women are excluded regardless of age, cardiac events, or vascular health, because they are women, because they are of child-bearing age,...