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This volume contains the proceedings of an interdisciplinary meeting which attracted participants from the fields of physics, engineering, applied mathematics, and geology. The subjects covered range from microscopic theories of friction to large-scale stick-slip motion in earthquakes, with static and dynamic aspects of granular material in between. The main emphasis is on computational aspects, but experiments and basic theoretical concepts are also covered.

Information on our detailed genetic code is increasing at a dramatic pace. We need to understand how that is translated into the three-dimensional structure of proteins in order to make use of the information. Progress in this field is hampered by the lack of precise force fields and of efficient codes for finding equilibrium configurations of heteropolymers. However, there has been rapid advance in recent years, and this volume discusses that.

Physicists, when modelling physical systems with a large number of degrees of freedom, and statisticians, when performing data analysis, have developed their own concepts and methods for making the best' inference. But are these methods equivalent, or not? What is the state of the art in making inferences? The physicists want answers. More: neural computation demands a clearer understanding of how neural systems make inferences; the theory of chaotic nonlinear systems as applied to time series analysis could profit from the experience already booked by the statisticians; and finally, there is...

Molecular dynamics is a well-established technique for simulating complex many-particle systems in many areas of physics, chemistry, and astrophysics. The huge computational requirements for simulations of large systems, especially with long-range forces, demand the use of massively parallel computers. Designing efficient algorithms for these problems is a highly non-trivial task.

This book contains the invited talks and abstracts presented at a conference by more than 100 researchers from various fields: computer science, solid state physics, high energy physics, polymers, biochemistry,...