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The cutting-edge Purine and Pyrimidine Metabolism in Man IX brings together contributions from internationally recognized researchers in the fields of molecular genetics, biochemical pharmacology, biochemistry, developmental biology, immunology, and epidemiology. This research has been crucial for the develoment of potent anticancer and antiviral drugs. A sampling of topics includes -- gout -- adenosine -- inborn errors of purine and pyrimidine metabolism -- mutations -- effects of hypoxia, free radicals, or reperfusion injury -- hot research areas, and -- cell differentiation and...

The author of this Foreword has recently retired after spending 25 years in academia and 15 years in the pharmaceutical industry. Most of this time has been spent following and, hopefully in some instances, contributing to advancement of the discipline of pharmacokinetics. During the last 40 years, pharmacokinetics has grown from a fledgling in the 1950s to an adult in the 1990s. The late development of the discipline of pharmacokinetics, relative to other disciplines such as chemistry, bio- chemistry, and pharmacology, probably stems both from general ignorance of the importance of the time...