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In this compilation, the pathogenesis and interrelationships of metabolic abnormalities are discussed, particularly their impact on cardiovascular disease, as well as the role of excess adiposity in metabolic derange. The authors discuss the literature on polycystic ovary syndrome and cardio-metabolic risk factors, providing recommendations that would be helpful for healthcare providers and policy makers. Additionally, the aspects of nutritional habits associated to an increase in cardiovascular risk factors in the obese population are addressed.