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The objective of present work was to develop a "tablets in capsule" system for facilitating both immediate and pulsatile drug deliveries of theophylline to mimic the circadian rhythm of nocturnal asthma. The system comprised of capsule filled with two tablets, first pulse and second pulse tablet prepared by wet granulation method. First pulse tablet was not coated and was responsible for providing loading dose whereas; second pulse tablet was coated with Eudragit L100 and Eudragit S100 to release drug in colon after specific lag time. Two independent variables, amount of polymers and coating...

Simulation of dynamic biochemical systems is receiving considerable attention due to increasing availability of experimental data of complex cellular functions.Numerous simulation tools have been developed for numerical simulation of the behavior of a system described in mathematical form. However,there exist only a few evaluation studies of these tools.The Knowledge of the properties and capabilities of the simulation tools would help bio-scientists in building models based on experimental data. Platelet aggregation is the clustering together of thrombocytes,which are the small,cell-like...