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In the present work we also thought it expedient, to conduct reactions in water under microwave irradiation to speed them up and then achieving total green chemical synthesis.Reactions under MWI though having the major drawback of not being suitable for scale-up to bulk quantities,this technique offers the advantages of being efficient and rapid and thus finds great utility as a tool in New Drug Discovery Research (NDDR) for the high throughput automated parallel syntheses of diverse compound libraries. We also thought to take take up this technique to generate focussed libraries of...

Supersaturable SMEDDS appeared to be an interesting approach to alleviate problems associated with oral delivery of Nebivolol. This can be achieved by using NEB-SMEDDS having the formula as Castor oil (30 %,v/v), Tween-80 (35 %,v/v), PEG-400 (35 %,v/v) and HPMC(5%)was successfully optimized to achieve higher release as well as bioavailability of NEB in F8 formulation of SMEDDS in comparison to plain drug suspension. Stability of the formulation was confirmed by thermodynamic stability study and long term stability study. The release and bioavailability from F8 SMEDDS was increased due to...