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Methanogenic archaea may have been among earth earliest organisms and today play essential roles in a variety of anaerobic habitants. The present investigation was to study the methanogen population in estuarine sediments in the mouth of Manimuthar River at the Palk Strait and seasonal sampling was made. Most Probable number (MPN) of methanogenic archaea was determined in the period of one year(2009). The archaeal populations were found to be at the maximum of 1.1x105 MPNgm-1 of wet sample during the post-monsoon season. The correlation co efficient (r) values calculated between the...

Avian influenza or Bird flu is a contagious disease of animals caused by viruses. Present day drugs are able to reduce the time to symptom resolution by 1.5 days provided therapy is started within 48 hours of the onset of symptoms, and have certain limitations. There is a need to develop a new drug that has high efficacy than present day drugs, by computer aided drug designing, binding affinity calculations including molecular mechanics based free energy calculations. Energy components calculated by performing molecular mechanics calculations both in explicit solvent and complex states are...