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It was found that mononuclear cells in the lung parenchyma of mice C57BL/6 after intratracheal administration of bleomycin demonstrated mesenchymal phenotype and express surface CD44, CD73, CD90, CD106, but did not express CD31, CD34, CD45. Bleomycin enhances the differentiation of MSCs in the direction of fibroblast cells in vitro and does not change the activity of adipogenic differentiation, at the same time chondrogenesis and osteogenesis are inhibited. Our results demonstrate that intranasal inoculation of pegylated hyaluronidase (pegHYAL), blocks bleomycin-induced lung injury and...

The model of irreversible bleomycin-induced pulmonary fibrosis shows that simultaneously with inflammatory cells in interstitial lung tissue of mice C57BL/6 cells with the phenotype Lin-, Sca-1+, c-Kit+, CD34- (HSCs) and hematopoietic progenitor cells (Lin-, Sca-1+, c-Kit+) are identified. During the phase of inflammation, HSCs of bleomycin lungs are characterized with high mitotic activity and the ability to differentiate into myeloid cell. Interstitial infiltration of alveolar ducts and alveoli by immature hematopoietic cells is accompanied by an increase in the level of multipotent...