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Sigma ( ) receptors are well established as an indipendent receptor family with its characteristic binding profile and distribution in the central nervous system. Activation of 1 receptors alters several neurotransmitter systems, in particular the dopamine (DA) neurotrasmission; however the exact role of 1 receptor in dopaminergic homeostasis remains unclear. The DA transporter (DAT) is the primary mechanism by wich dopaminergic neurons terminate the signal, thus regulating the temporal aspects of dopaminergic synaptic transmission. This study shows for the first time that, in cell models, 1...