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Alcohol dependence is a debilitating disorder for the
individual and very costly for society. Because
alcoholism is such a complex disease, animal models
are used to mimic components of the disease.
Alcoholism is defined by cycles of intoxication and
abstinence, resulting in the compulsion to drink
alcohol, loss of control in limiting intake, and
emergence of negative emotional states. These studies
focused on behaviors during protracted abstinence in
rats genetically and environmentally susceptible to
alcohol dependence. Specifically, rats selectively
bred for high alcohol preference were...