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The majority of invasive meningococcal disease in developed countries is caused by Neisseria meningitidis with a serogroup B capsule. Despite, the availability of vaccines for other serogroups since the 1960s, no broadly effective vaccine has been developed for prevention of meningococcal serogroup B disease. However, with the increasing availability of microbial genome sequence information along with the recent advancements in the field of bioinformatics, it is now possible to identify potential protein targets of immune response that would certainly be useful in reducing the time and cost...

This book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics.The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes...