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Hepatitis C virus (HCV), first described in 1989, is now recognized as one of the main causes of chronic liver disease worldwide. HCV infection becomes chronic in the majority of cases. All current treatment protocols for hepatitis C are based on the use of interferon alpha and ribavirin (RBV). Despite RBV broad spectrum in treatment of various viral infections, recently several reports revealed genotoxic effects of RBV in vivo and in vitro. This genotoxicity was correlated with the production of reactive oxygen species (ROS). This study aimed to evaluate RBV genotoxicity and investigate the...

Fasciolosis is a liver disease caused by Fasciola hepatica or F. gigantica that causes significant economic loss in cattles, other animal species and man. The appearance of Fasciola hepatica populations that are resistant to common flukicidal drugs make a need for the development of anti-liver fluke vaccines. Though we selected a target Fasciola gene that expresses (rFhp) protein, in which its native form shows significant induction to lymphoproliferative response of Peripheral blood mononuclear cells. Then we amplified the gene through Polymerase chain reaction process using gt11 specific...