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Acute and chronic usage of morphine cause degeneration of some parts of brain which responsible for cognition activity such as learning and memory .In this study we investigate the Acute, sub acute, sub chronic and chronic administration of morphine on learning and memory by using Moris Water Maze, Active Avoidance Test and Passive Avoidance Test. Our data demonstrated that acute administration of morphine does not impact on cognition behavior but sub acute, sub chronic and chronic administration of morphine can be alter learning and memory. Thus, morphine abuse in addition to dependency can...

Morphine withdrawal is usually encountered with unsuccessful outcomes and using of alternative substances such as methadone, despite partial benefits and due to the lack of a mental tranquility during the withdrawal period, may not lead to the desired result. In this study morphine itself has been used to management morphine dependence, using an animal model. Forty adult male mice were divided into 5 groups including: independent negative control group, dependent positive control group, dependent group under treatment by increasing intervals of dosage, dependent group under treatment by...

Chronic use of morphine and alcohol lead to dependency and discontinuation of these drugs causes physical and emotional changes which need pharmacological and non pharmacological intervention. In this study exercise had been used as an allied therapy to relives morphine and alcohol addiction. Total Withdrawal Score (TWS) significantly decreased in all test groups in comparison with positive control group (without treatment). The results showed it would be feasible to use exercise to reduce of the withdrawal symptoms in the dependent people. Actually our study showed that exercise can be...

Acute and chronic usage of morphine cause degeneration in some parts brain which responsible for anxiety and depression. In this study we investigate the acute, sub acute and chronic administration of morphine on withdrawal syndrome, anxiety and depression by using Forced swim test, Elevated Plus maze, Open Filed Test. Our data demonstrated that acute administration of morphine does not impact on withdrawal syndrome, anxiety and depression, but sub acute, and chronic administration of morphine can be alter withdrawal syndrome, anxiety and depression. Thus, morphine abuse in addition to...