Synthesis and Biological Evaluation of Some New Imidazoles : New Imidazoles

ISBN-13: 9786202514323 / Angielski

Sobhi Gomha; Mohammed Bauomi

Opis

This work has been carried out to investigate the following: The first project represents the reactions of ethylidenethiosemicarbazone with DMAD or substituted methylenemalononitriles gave thiazolidin-4-one or 1,3-thiazine derivatives, respectively. Also, treatment of ethylidenethiosemicarbazide with hydrazonoyl halides, -haloketones, and chloroacetic acid afforded the corresponding arylazothiazoles, thiazoles, and thiazolidenone derivative, respectively. The anti-cancer activity of the selected products against the colon carcinoma cell line (HCT-116) was determined and the results revealed promising activity.The second project involves the synthesis of a novel series of pyridine and bipyridine derivatives is described via one-pot multi-component reaction of 5-acetylimidazole, malononitrile (or ethyl cyanoacetate or diethyl malonate), substituted benzaldehyde (or terephthaldehyde) and ammonium acetate in good yields. The antimicrobial activities of the synthesized compounds were screened and the results showed that most of them exhibit considerable activities. Also, some of the newly synthesized compounds were screened for their anticancer activity against two cell lines.

O autorze

Gomha, Sobhi
Prof. Sobhi M. Gomha has been published 167 scientific papers in the fields of synthetic organic chemistry, chemistry of hydrazonoyl halides, chemistry of enaminones, green chemistry and bioactive heterocyclic chemistry (There are about 2500 citations of his work until March 2020 (h-index 28). He supervised 20 M.Sc. and Ph.D. graduate theses.