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The first concept of solid phase synthesis was performed by Merrifield (1) in a dipeptide synthesis from two amino acids. Not surprisingly, Solid phase synthesis did not remain limited to peptides, but also it was extended to heterocycles, so many synthesis methods in solution phase had been transferred to solid phase processes.So, solid phase organic synthesis had become very attractive route of synthesis due to its simplicity of separation of synthetic intermediates from soluble components of a reaction mixture by simple filtration and washing of the resin bound reaction product.

This study comprises a brief literature survey on the chemistry and biological activity of the bridgehead nitrogen thiazolopyrimidines. In addition to, the synthesis of certain new substituted and fused thiazolopyrimidines, some of these compounds were subjected to preliminary screening for their antimicrobial activity.The structural elucidation of the new compounds was supported by elemental analyses, IR, 1H-NMR, in addition to mass spectrometry on demand. Some of the new compounds were subjected to preliminary antimicrobial testing and the data obtained are summarized.