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Translation, i.e. protein synthesis, studied from a genetic viewpoint is illustrated in this volume, demonstrating how researchers are employing both classical genetic and recombinant DNA techniques in studying the components, mechanisms, regulation and accuracy of protein synthesis. Both the prokaryotic (especially Escherichia coli) and eukaryotic (especially Saccharomyces cerevisiae) system are discussed, presenting both new information and the new genetic approaches available. This book does not concentrate on one particular aspect of translation, but provides an ideal...

The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques that began in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all levels. The resulting investigations revealed a diversity of post-transcriptional mechanisms in both prokaryotes and eukaryotes. Scientists working on translation, mRNA stability, transcriptional...

Due to fundamental similarities between the yeast Saccharomyces cerevisiae and multicellular organisms at the molecular level, and the powerful range of experimental tools available for this yeast, S. cerevisiae is proving an ideal model system for studies on protein synthesis and targeting. The topics covered are: - Messenger RNA stability and translation.- The translation apparatus. - Translational control andfidelity. - Protein targeting to the mitochondrion. - Nuclear transport. - The secretory pathway. - Protein folding and degradation. - Protein splicing. Modern and often novel...