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Dr. Ben Appelstein and his team of students unwittingly unleash an ancient plague on the modern world, derailing their promising lives and threatening to extinguish life as we know it.

Against a backdrop of war and disease, four friends fight through transformative journies both personal and monumental: Rich, a brilliant gay athlete struggling for esteem; Wendy, a querulous coed caught between two men and an uncertain future; Halfus, a quiet hero with a tragic past; and Ernie, a fun-loving charmer with aspirations of...