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Dopamine, involved in the etiology of CNS related disorders such as Parkinsons disease, shows poor CNS disposition following oral and IV administration due to its extensive metabolism in the GI tract and poor permeation of the blood brain barrier. However, enhanced CNS uptake of dopamine was observed following intranasal administration. Western blotting and microscopy studies revealed the expression and presence of Dopamine Transporter (DAT) and Organic Cation Transporter-2 (OCT-2) in the nasal mucosa. Bi-directional transport studies demonstrated the role of both transporters in nasal...