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A simple spectrophotometric method for determination of cefaclor in raw and dosage forms based on reaction with ninhydrin is developed, optimized and validated. The purple color (Ruhemenn s purple) resulted from the reaction was stabilized and measured at 560 nm.The method optimization was essential as many procedural parameters influenced the accuracy of determination all variables including the reagent concentration, heating time, reaction temperature, color stability period, and cefaclor/ninhydrin ratio were studied in order to optimize the reaction conditions. No interference was observed...

An extensive literature assessment is done and it is obvious that the methods are accessible for Ranitidine. HPLC is very expensive instrument and are not available in every laboratory. While UV/Visible spectrophotometer is a common instrument of all pharmaceutical analytical laboratory. Spectrophotometric analysis methods available for Ranitidine are tedious, time consuming and not much sensitive in term of precision and accuracy. It becomes essential to develop new rapid and cost effective methods that spectrophotometric determination would be simple, accurate, precise and sensitive. The...

Colonic drug delivery system has achieved great significance in the treatment of local diseases of colon. Microcapsules are particularly appealing for the development of controlled or targeted release dosage forms. They play significant role as drug delivery systems aiming at enhanced bio availability of conventional drugs and minimizing side effects. The formulated microcapsules provide the pH dependent targeted release which proved that microcapsules are excellent candidate for site specific colon drug delivery.