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Project Report from the year 2013 in the subject Biology - Neurobiology, grade: 1.0, University of Gottingen, language: English, abstract: Genetic engineering is known as a powerful technique for basic research and clinical applications. Recent progress in development of zinc-finger nucleases (ZFNs), which combine the DNA cleavage ability of Fok1 restriction enzyme with highly specific recognition properties of zinc-finger motifs, allows to improve efficiency and to broaden the field of use of genome editing. Here, we demonstrate our initial results in generating novel tools for Cathepsin D...

Internship Report from the year 2012 in the subject Biology - Neurobiology, grade: 1,3, University of Gottingen (Max Plank Institute for Experimental Medicine / Department of Neurogenetics), language: English, abstract: Tetraspanin2 (Tspan2) is a member of the tetraspan/transmembrane4 superfamily restricted to the nervous system. The abundance of Tspan2 is low in physiological condition but increases greatly in myelin of PLP-deficient mice which may indicate its' compensatory functions. Our experiments show that Tspan2 has no effect on delay of myelination at P14; young and old mice lacking...

Project Report from the year 2013 in the subject Biology - Diseases, Health, Nutrition, grade: 1.3, University of Gottingen (Max Plank Institute for Experimental Medicine), language: English, abstract: Kv10.1, the voltage-gated non-inactivating delayed rectifier potassium channel, is overexpressed in variety of cancer cells and is involved in oncogenesis and tumor progression. Its splice variants E65 and E70, which were discovered in melanoma cell lines, have no conducting abilities but may physically interact with Kv10.1 and thereby regulate its function. Here, we investigated possible...