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Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo- ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re- markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a .'s chapter puts into a historical perspec- tive how our notions...

Immunity studies in sharks over the past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the development evolution of our own immune system.

Immunobiology of the Shark describes the cellular, genetic, and molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the shark from basic microscopic observations to detailed genome...