Wyniki wyszukiwania:

This multidisciplinary overview covers basic concepts related to the discovery of the Hepatitis C virus, development of serological and nucleic acid tests to detect infection, the structure of the virus genome, generation of virus gene products, and proposed replication scheme. The volume discusses the epidemiology, transmission, pathogenesis of infection, the development of hepatocellular carcinoma associated with chronic virus infection, and current strategies for treatment. It also discusses advances in cell culture systems, animal models of infection, and emerging treatments and vaccine...

Since the discovery of Australia antigen and its association with type B hepatitis, molecular characterization of the components making up hepatitis B virus (RBV) have been pursued with worldwide interest. Over the past two decades, such characterization has led to the development of sensitive assays to screen and exclude contaminated units from blood banks and has recently resulted in the licensing of several RBV vaccines. That more than 200 million people worldwide are chronically infected with RBV, and that they are at a high risk for the development of chronic hepatitis and hepatocellular...

Hepatocellular carcinoma (HCC) is a common tumor type arising from several distinct etiologies. It is usually diagnosed late and is difficult to treat. This volume presents an overview of selected aspects of HCC pathogenesis, and research aimed at developing diagnostic biomarkers. It points to a number of putative therapeutic targets, including signal transduction pathways, metabolic and epigenetic alterations in tumor cells, the tumor microenvironment, the gut microbiome, and functions of immune effector cells. Given the multi-step nature of most cancers, including HCC, future drug...