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In this book we highlight the strong synthetic potential and scope of transition metal-catalyzed rearrangement reactions for fully economical and complex carbon-carbon bond forming reactions. The Meyer-Schuster and the Rupe rearrangements are emerging as the methods of choice for the homologation of carbonyl compounds into, -unsaturated aldehydes and ketones, particularly useful for the synthesis of many hindered ketones. The Rautenstrauch-I and Rautenstrauch-II rearrangements of readily propargylic derivatives are very useful reactions for the synthesis of complex cyclopentenones, and...

The heterocyclic quinoline ring system is the core structure of a number of natural and non-natural synthetic molecules endowed with interesting biological activities, and or physical properties. Accordingly, a number of methodologies for the synthesis of quinolines have been developed. The Friedlander reaction is still one of the most efficient and simplest methods. The Friedlander reaction is the base or acid promoted condensation of an aromatic 2-amino-substituted carbonyl compound with a carbonyl derivative bearing a reactive alfa-methylene group, followed by cyclodehydration. In this...