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New developments in the surgical management of breast disease surgery daily. New techniques for tumor resection, reconstructive surgery, lymph node assessment and cosmetic surgery are surfacing due to new demands in the market. The treatments are aimed at those patients diagnosed with breast disease who need quality medical treatment and require equally pleasing aesthetic results. This is an international text that outlines the management of both the malignant and benign diseases of the breast. High quality illustrations accompany the text to highlight the key aspects of surgical techniques....

Transcription factors are key players in the execution of the genomic program of any given cell. Their control over complex patterns of gene expression governs essentially every step in the development, growth and differentiation of an organ ism as well as its physiological responses to external stimuli. An Introduction to Transcription Factors, the first part of this volume, de scribes the varied and combinatorial mechanisms involved in the two basic modes of transcriptional control, activation (the chapter by Herrera et al.) and repression (the chapter by Arnosti). Overlaying both modes is...

Die hormonelle Therapie hat seit langer Zeit einen festen Stellenwert in der Behandlung des Mammakarzinoms. 1m Juni 1895 ftihrte der schottische Chirurg Beatson die erste Ovarektomie als therapeuti- sche MaBnahme bei einer Patientin mit lokal fortgeschrittenem Mammakarzinom durch, welche durch eine Operation an der Brust allein nicht mehr sinnvoll zu behandeln war. Aus AniaB dieser historischen Pioniertat initiierte ZENECA, als weltweit forschendes Unternehmen auf dem Gebiet der hormo- nellen Krebstherapie, genau 100 Jahre spater ein wissenschaftliches Symposium zum Thema ,,100 Jahre...