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Despite substantial evidence showing the feasibility of Atomic Force Microscopy (AFM) to identify cells with altered elastic and adhesive properties, the use of this technique as a complementary diagnostic method remains controversial. This book is designed to be a practical textbook that teaches how to assess the mechanical characteristics of living, individual cells by AFM. Following a step-by-step approach, it introduces the methodology of measurements in the case of both determination of elastic properties and quantification of adhesive properties.

This book is dedicated to the discussion of several biomedical applications of the mechanical phenotyping of cells and tissues to specific disease models. The topical chapters on mechanics in disease are preceded by chapters describing cell and tissue structure and their relationship with the biomechanical properties, as well as by the description of dedicated sample preparation methods for the nano- and microscale mechanical measurements.

The mechanical properties of cells can be used to distinguish pathological from normal cells and tissues in many diseases. This two-volume work outlines the physics behind cell and tissue mechanics, describe the methods which can be used to determine their mechanical properties, and present various diseases in which a mechanical fingerprint could be established. Vol. 1. Biomedical Methods. Vol. 2. Biomedical Applications.