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The goal in designing sustained release is reduce the frequency of dosing or to increase the effectiveness of the drug by localization at the site of action, reducing the dose required or providing the uniform drug delivery. The use of controlled release (CR) formulations offers many potential advantages such as, sustained blood levels attenuation of adverse effects and improved patients compliance. It is important especially in the case of antihypertensive agents, to maintain constant blood levels, as other wise, dose dumping may cause hypo tension and sub-therapeutical levels may cause...

Efficiency in the drug discovery process relies on timely knowledge of biological drug-response in the course of disease and treatment, which ultimately rests on knowledge of protein function and regulation. As proteomics deals with the root level of the protein function, there is a very high probability that this will be one of the major tools of modern drug discovery process. Proteomics is being considered as one of the major drug discovery tools by the scientists. Global gene expression profiling by genomic and proteomic analyses has changed the face of drug discovery and biological...