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Urbanization has significantly impacted water bodies, as seen in Peddacheruvu, an urban lake in Mahabubnagar, India. Rapid urban growth has led to contamination from human waste and heavy metals. This study assesses the lake's water quality through physico-chemical and microbiological analysis, following the American Public Health Association guidelines.Physico-chemical analysis revealed high pollution levels, including toxic metals like lead, cadmium, and chromium. These pollutants pose threats to aquatic life and public health. In parallel, microbiological studies identified resilient...

The objective of this work was to develop of a suitable SR tablet formulation of Eplerenone and to study the effect of polymers such as HPMC K4M, HPMC K15M, NaCMC, Guar gum, Xanthan gum and Karaya gum on drug release. Profile and to get an optimized formulation. Eplerenone binds to the mineralo corticoidreceptorand blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). It has a half life of 4 hrs. When dose is missing it may cause nocturnal attack, so attention was made to develop the Sustained release tablets of Eplerenone. The purpose of...