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Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology...

Social entrepreneurship is a hot topic in public and non-profit management. Organizations everywhere are looking for innovative ways to respond to financial, social, and regulatory pressures. The next generation of transformative leaders will be risk takers who know how to face even the biggest challenges using market-driven strategies that get results. This book contains everything students and professionals need to know about the cutting-edge practice of social entrepreneurship.

In Social Entrepreneurship, you'll learn how to read...

As quality becomes an increasingly essential factor for achieving business success, building quality improvement into all stages product planning, product design, and process design instead of just manufacturing has also become essential. Quality Engineering: Off-Line Methods and Applications explores how to use quality engineering methods and other modern techniques to ensure design optimization at every stage. The book takes a broad approach, focusing on the user s perspective and building a well-structured framework for the study and implementation of quality engineering.

Starting...

Cloud computing is the most significant technology transformation since the introduction of the Internet in the early 1990s. As more and more companies and educational institutions plan to adopt a cloud-based IT infrastructure, today s job market requires IT professionals who understand cloud computing and have hands-on experience developing cloud-based networks. Cloud Computing Networking: Theory, Practice, and Development covers the key networking and system administration concepts as well as the vital hands-on skills you need to master cloud technology.

This book is...

To help readers understand virtualization and cloud computing, this book is designed to cover the theories and concepts enough to understand the cutting-edge technology. Meanwhile, in this book, the reader can gain hands-on skills on VMware Cloud Suite to create a private cloud. With the academic support from VMware, readers can use the VMware supported software to create various virtualized IT infrastructures sophisticated enough for various sized enterprises. Then, the virtualized IT infrastructure can be made available to an enterprise through the private cloud services.

The C-C bond is a basic building block in chemistry, and its formation is often the first step towards building more complex molecules. The direct generation of C-C bonds from C-H by cross-dehydrogenative-coupling (CDC) reactions in 2003 has presented a paradigm shift towards more efficient synthetic design, and over the last decade this has become a hot topic in Green Chemistry.

This edited book presents a summary of the latest developments in the formation of C-C bonds direct from two different C-H bonds via oxidative dehydrogenative couplings. The editor, (CJ Li, McGill University)...

This book divides the history of China's rural-urban relations into three stages: antagonism, integration and re-antagonism, and demonstrates that the two coupled variables i.e., policy-culture and coast-trade are the most crucial to urbanization and rural-urban governance in China from ancient times till now. From the perspective of a combination of history and geography, this book puts forward a new theory which is mainly based on Adam Smith's theory and other theories about rural-urban relationship and reinterprets the process and driving forces of evolutionary history of rural-urban...