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High-pressure liquid chromatography (HPLC) used in the analytical development to quantify the biological sample concentration, the active pharmaceutical ingredient (API) and to evaluate the impurity and degradation product profiles of the drug substances (DS) and drug products (DP). Additional uses of HPLC include determination of content uniformity of dosage form, monitoring of dissolution profiles, determination of antioxidants and preservative content and supporting of cleaning validations. UV spectroscopy is one of the most frequent used techniques in pharmaceutical analysis. It involves...

The objective of the present study was to develop and validate a HPLC method with good sensitivity and specificity for the identification and quantification of trimetazidine in human plasma. Trimetazidine and caffeine (internal standard) were isolated from plasma samples by protein precipitation with methanol. The chromatographic separation was accomplished on a Xterra C18 Column with the mobile phase consisting of potassium di-hydrogen phosphate buffer-acetonotrile-triethylamine (90:10:0.04, v/v) (pH 4.16, adjusted with ortho-phosphoric acid), and the flow rate was set at 1.0 mL/min....

The purpose of the 'Clinical Ophthalmology and Ophthalmic Products Manufacturing', is to present the basics of clinical ophthalmology practice in a systematic and succinct manner. I have tried to be comprehensive in the inclusion of key points. The majorities of explanations are latest and provide an effective and vivid representation of many conditions. The book is intended principally for the trainee and practicing ophthalmologist.