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The discovery of chlorpromazine for the specific treatment of schizophrenic symp toms and, later on, of imipramine for the specific treatment of depressive symptoms marked a new milestone in clinical psychiatry and basic neuroscience 40 years ago. The exploration of biochemical mechanisms of action of these psychotropic drugs created new theories on the pathophysiology of psychiatric disorders, such as the dopamine hypothesis of schizophrenia and the catecholamine and serotonin hypotheses of depression. Thus the discovery of these biological treatments had a major impact on natural...

The volumes on "psychotropic substances" in the Handbook of Experimental Phar- macology series clearly show that the classical concept of this discipline has become too narrow in recent years. For instance, what substances are psychotropic is determined not by the criteria of the animal trial, i.e. by experimental pharmacology, but by their action on the psy- che, which in the final analysis is only accessible to us in man. Psychotropic substances force experimental pharmacology (and thus also this Handbook) outside its tradition- allimits, which have essentially depended on animal studies....

Mehr als die Halfte aller Patienten weisen Krankheiten mit seelischen Storungen oder mit einer psychosomatischen Atiologie auf. Dementsprechend wichtig ist es, sowohl fur Studierende als auch fur Arzte aller Fachdisziplinen, die Grundlagen der psychosomatischen Medizin zu beherrschen. Im "Klussmann" werden die wichtigsten Krankheitsbilder aller klinischen Fachgebiete aus psychosomatischer Sicht behandelt. Dabei erleichtern Einleitungen und Definitionen den Einstieg in die Materie, zahlreiche Fallbeispiele sorgen fur Anschaulichkeit und stellen den Bezug zur Praxis her. Umfangreiche Hinweise...

This volume contains the proceedings of the symposium Pathochemical Markers in Major Psychoses, held in Vienna in July 1983. The development of biological markers in psychiatric diseases, par ticularly in the field of neurochemistry, has made substantial progress during recent years although the multiple mechanisms of mental illness are still not fully understood. The greatest contribution has come through the development of new therapeutic agents that not only pro vide invaluable help for psychiatric patients but also serve as chemical tools for the investigation of the biological mechanisms...