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This book provides a comprehensive review of the field of peptide biosynthesis. Individual chapters range from historical perspectives of the field to current knowledge regarding specific enzymes. Every step from gene to final bioactive peptide is covered in detail. Approximately two thirds of the book reviews the enzymes responsible for intracellular and extracellular peptide processing. Other chapters cover issues such as tissue-specific processing and the subcellular sorting of the peptides. New areas covered include the discovery, purification, characterization, and cDNA cloning of...

Neuropeptides and peptide hormones represent the largest class of chemical messengers that transmit information from one cell to another. In this review, several decades of research on peptides in cell-cell signaling are summarized, with a focus on neuropeptide discovery, biosynthesis, and function. In addition to covering the well-studied aspects of neuropeptides, emerging concepts are discussed, including classical versus non-classical neuropeptides and direct versus indirect neuropeptides. Other potential functions for peptides in intercellular and intracellular signaling are also...

Science is a great profession. As a scientist, you actually get paid to have fun all day and night What could be better? This book is focused on the career path of an active research scientist, from post-doctoral training to that of group leader running a successful research program. Most of the essential things you need to succeed as a scientist and group leader are not taught in school. Topics covered in this book include the process of finding a job, setting up a lab, making major discoveries, and moving up the ranks. Some chapters include essential things for all scientists, such as...

Many people think that they do not need a book on "how to write a really bad grant application" - they already know how. Actually, this book is intended as a guide to writing grant applications that will get funded. One way to write a good grant application is to avoid writing a bad one. This book analyzes "bad" scientific grant applications from a humorous perspective. There are also some sections on obtaining funding from private foundations and industry, and a few parts that are pure silliness. All pieces in this book are original and are either fiction (the humor pieces) or non-fiction...