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This book assesses techniques used in therapeutic development across the product lifecycle from early discovery through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, commercial support and more.

This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution. It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions. Reviews of research on three disparate biomolecular machines--DNA helicases, ATP synthases, and myosin--illustrate how the...