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Over the past two decades in Taiwan, the incidence of breast cancer is increasing. The equivalent peak of Taiwanese occurred about 10 years younger that United States. Younger than 45 years old female (pre-menopause) breast cancer women were increasing rapidly in Taiwan. But, gene line mutation of Asian-Pacific countries, such as China, Taiwan, Korea, Japan and Malaysia occurred significant lower than Caucasian women with breast cancer. Chemical hormone replacement therapy that may cause breast cancer is not as popular in Taiwan as in Western countries. To explain this by epidemiology,we...