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Advances in science and technology over the last century have greatly expanded our knowledge about pathogenesis of periodontal diseases and defining new paradigms for dentistry. Periodontitis is one of the most common and often undiagnosed human disease, mostly gram-negative chronic infection of the tooth-supporting structures which if left untreated will progress to alveolar bone destruction and ultimately followed by tooth loss. Recent evidence suggests that periodontal infection may significantly enhance the risk of certain systemic disease or alter the natural course of systemic disease...