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In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation...

In October 1998, key leaders of new drug discovery for inflammatory di seases gathered at Hershey, Pennsylvania, for the 10th International C onference of the Inflammation Research Association. The conference pro vided a stimulating environment for the open exchange of important adv ances in basic inflammation research and new drug discovery and develo pment. This book encompasses highlights of several presentations made at the conference and contains some of the latest and important develo pments in the field of inflammation research.

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two-volume set discusses...